Table 1 Effect of Metformin administration on lung histopathology in the late stage
From: Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
| Groups | Lesion severity grade | Average severity grade | Lesion distribution grade | Average distribution grade | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | 0 | 1 | 2 | 3 | 4 | 5 | |||
| Saline | 6 | – | 6 | – | ||||||||||
| Silica | 1 | 2 | 3 | 4.33 ± 0.33 | 1 | 1 | 3 | 1 | 3.67 ± 0.42 | |||||
| Silica + 100 mg/kg metformin | 2 | 4 | 3.67 ± 0.84 | 2 | 4 | 1.67 ± 0.21a | ||||||||
| Silica + 300 mg/kg metformin | 1 | 3 | 1 | 1 | 1.67 ± 0.71a | 1 | 4 | 1 | 1.00 ± 0.26a | |||||