Table 1 GRP78-targeted drug therapies for cancer treatment
From: GRP78 in lung cancer
| Drugs | Effects | Study |
|---|---|---|
| Versipelostatin | Inhibits transcription factors | Colon and stomach cancer [105] |
| EGCG | Binds to ATP binding domain and alters ATPase activity | Breast cancer [103] |
| Subtilase cytotoxin (AB5) | GRP78 proteolytic cleavage | Lung cancer [104] |
| GIRLRG | Targets cell surface GRP78 |
Lung cancer [119], glioma, and breast cancer [117] |
| CTVALPGGYVRVC | Melanoma [114] | |
| WIFPWIQL | Prostate and breast cancer [116] | |
| Bag-1 peptide | Prostate cancer [118] | |
| Antibody | Lung cancer and glioblastoma [113] | |
| Kringle 5 (K5) | Fibrosarcoma [111] |